Disruption of<i>ins-11</i>, a<i>Caenorhabditis elegans</i>Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal
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- KAWANO Tsuyoshi
- Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
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- NAGATOMO Ryosuke
- Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
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- KIMURA Yasuo
- Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University
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- GENGYO-ANDO Keiko
- Department of Physiology, Tokyo Women’s Medical University School of Medicine CREST, JST
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- MITANI Shohei
- Department of Physiology, Tokyo Women’s Medical University School of Medicine CREST, JST
書誌事項
- タイトル別名
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- Disruption of ins-11, a Caenorhabditis elegans Insulin-Like Gene, and Phenotypic Analyses of the Gene-Disrupted Animal
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抄録
The insulin/insulin-like growth factor-I signaling (IIS) pathway regulates larval diapause, adult lifespan, fat metabolism, and stress-resistance in the nematode Caenorhabditis elegans. One of 38 C. elegans insulin-like genes, ins-11, was disrupted and phenotypic analyses of the gene-disrupted animal were performed. The gene-disruption exhibited a significant influence on the adult lifespan. It antagonized the lifespan extension induced by RNAi knockdown of another insulin-like gene, ins-7. Hence ins-11 appears to be necessary for lifespan extension caused by a decrease in the IIS pathway. This is the first description of gene-disruption of the C. elegans insulin-like gene that suppresses the lifespan extension.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (12), 3084-3087, 2006
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206477109760
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- NII論文ID
- 10018524365
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8597090
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可