Wheat Bran Protects Fischer-344 Rats from Diquat-Induced Oxidative Stress by Activating Antioxidant System: Selenium as an Antioxidant
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- HIGUCHI Masashi
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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- OSHIDA Junichi
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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- ORINO Koichi
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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- WATANABE Kiyotaka
- Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Kitasato University
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Wheat bran had a protective effect against diquat toxicity in rats fed a purified diet (PD). We studied the effects of wheat bran on the antioxidant system in the liver of rats treated with saline and diquat. Although feeding wheat bran did not affect the concentration of hepatic non-protein sulfhydryl or the activity of glucose 6-phosphate dehydrogenase in the saline-injected rats, these values were significantly higher in the rats fed PD containing wheat bran (W-PD) than in rats fed only PD after administering diquat. The glutathione peroxidase and reductase activities were significantly elevated by wheat bran in the saline-injected rats. Although the glutathione peroxidase activity was unchanged in both the PD-fed rats and W-PD-fed rats after the diquat treatment, the glutathione reductase activity was significantly decreased in both the PD-fed and W-PD-fed rats. Feeding the rats with PD containing 0.15 ppm selenium as well as with W-PD elevated the activity of hepatic glutathione peroxidase and attenuated the diquat toxicity. These results indicate that wheat bran protected against diquat toxicity by activating the hepatic antioxidant system, and that selenium was the key antioxidant in wheat bran.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (3), 496-499, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206477139328
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- NII論文ID
- 10028201670
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11051612
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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