Gene sequencing and tissue expression of unknown isoforms of an angiotensin 2 type 2 receptor interacting protein, ATIP, in the rat

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  • KREZEL Michael Angus
    Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health
  • REZMANN Linda Adriana
    Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health
  • VARGHAYEE Naghmeh
    Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health
  • PETE Josefa
    Baker International Diabetes Institute
  • FRAUMAN Albert George
    Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health
  • LOUIS Simon Nicholas Stewart
    Clinical Pharmacology and Therapeutics Unit, University of Melbourne, Department of Medicine, Austin Health

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  • Gene Sequencing and Tissue Expression of Unknown Isoforms of an Angiotensin II Type 2 Receptor Interacting Protein, ATIP, in the Rat

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To investigate the expression of the unknown angiotensin II type 2 receptor interacting protein (ATIP) isoforms in the rat we used the known sequences of human and mouse ATIP to design sequencing primers to enable us to sequence rat ATIP3 and ATIP4. Exon 4, which is present in human but not mouse ATIP, was not identified in the coding region of rat ATIP. The expression levels of these genes in a range of rat tissues were examined, and we concluded that there is little similarity in the relative tissue distribution of the various ATIP isoforms in rat and human.

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