Lithospermi radix Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells

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  • KIM Eun Kyoung
    Department of Anatomy, College of Oriental Medicine, Kyung Hee University
  • KIM Eun-Young
    Department of Anatomy, College of Oriental Medicine, Kyung Hee University
  • MOON Phil-Dong
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
  • UM Jae-Young
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
  • KIM Hyung-Min
    Department of Pharmacology, College of Oriental Medicine, Kyung Hee University
  • LEE Hyun-Sam
    Department of Anatomy, College of Oriental Medicine, Kyung Hee University
  • SOHN Youngjoo
    Department of Gynecology, College of Oriental Medicine, Sangji University
  • PARK Seong Kyu
    Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University
  • JUNG Hyuk-Sang
    Department of Anatomy, College of Oriental Medicine, Kyung Hee University
  • SOHN Nak-Won
    Department of Anatomy, College of Oriental Medicine, Kyung Hee University

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  • <i>Lithospermi radix</i>Extract Inhibits Histamine Release and Production of Inflammatory Cytokine in Mast Cells

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Lithospermi radix (LR, Borraginaceae, the root of Lithospermum erythrorhizon Siebold. et Zuccarinii) is used in herbal medicine to treat such conditions as eczema, skin burns and frostbite. This study investigates the effects of LR on the anti-allergy mechanism. LR inhibited the release of histamine from rat peritoneal mast cells by compound 48/80 in a dose-dependent manner. LR orally administered at 6.59 mg/100 g also inhibited the anti-DNP IgE-induced passive cutaneous anaphylaxis reaction. LR inhibited the PMA plus A23187-induced increase in IL-6, IL-8, and TNF-α expression in HMC-1 cells. In addition, LR also inhibited nuclear factor-kappa B (NF-κB) activation and IκB-α degradation. These results show that LR had an inhibitory effect on the atopic allergic reaction. Furthermore, the in vivo and in vitro anti-allergic effect of LR suggests possible therapeutic applications of this agent for inflammatory allergic diseases.

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