<i>Ganoderma lucidum</i>Extracts Inhibited Leukemia WEHI-3 Cells in BALB/c Mice and Promoted an Immune Response<i>in Vivo</i>

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  • CHANG Yung-Hsien
    Graduate Institute of Acupuncture Science, China Medical University
  • YANG Jai-Sing
    Department of Pharmacology, China Medical University
  • YANG Jiun-Long
    Graduate Institute of Chinese Pharmaceutical Science, China Medical University
  • WU Chang-Lin
    Department of Biological Science and Technology, China Medical University
  • CHANG Shu-Jen
    School of Pharmacy, China Medical University
  • LU Kung-Wen
    Graduate Institute of Chinese Medical Science, China Medical University
  • LIN Jen-Jyh
    Graduate Institute of Chinese Medical Science, China Medical University
  • HSIA Te-Chun
    Graduate Institute of Chinese Medical Science, China Medical University Department of Internal Medicine, China Medical University Hospital
  • LIN Yi-Ting
    Department of Biological Science and Technology, China Medical University
  • HO Chin-Chih
    Department of Biological Science and Technology, China Medical University
  • WOOD W. Gibson
    Department of Pharmacology, University of Minnesota, School of Medicine and Geriatric Research, Education and Clinical Center, VA Medical Center
  • CHUNG Jing-Gung
    Department of Biological Science and Technology, China Medical University Department of Biotechnology, Asia University

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  • Ganoderma lucidum Extracts Inhibited Leukemia WEHI-3 Cells in BALB/c Mice and Promoted an Immune Response in Vivo

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Ganoderma lucidum (G. lucidum) is a medicinal mushroom having biological effects such as immunomodulation and anti-tumor actions. In China and many other Asian countries, G. lucidum is used as a folk remedy to promote health and longevity. Although many studies have shown that G. lucidum modulates the immune system, including, for example, antigen-presenting cells, natural killer (NK) cells, and the T and B lymphocytes, the effects of G. lucidum on the WEHI-3 leukemic BALB/c mice are unclear. We attempted to determine whether G. lucidum would promote immune responses in BALB/c mice injected with WEHI-3 leukemia cells. The effects of G. lucidum on the survival rate of WEHI-3 leukemia cells injected into BALB/c mice were examined. It increased the percentages of CD3 and CD19, but decreased the percentages of Mac-3 and CD11b markers, suggesting that differentiation of the precursor of T and B cells was promoted but macrophages were inhibited. It decreased the weight of spleens as compared with control mice. It also promoted phagocytosis by macrophage from peripheral blood mononuclear cell (PBMC) and it also promoted natural killer cell activity. It decreased the percentage of leukemia cells in the spleens of mice before they were injected with WEHI-3 cells. Apparently, G. lucidum affects murine leukemia WEHI-3 cells in vivo.

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