LGR4 Is Required for the Cell Survival of the Peripheral Mesenchyme at the Embryonic Stages of Nephrogenesis

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  • MOHRI Yasuaki
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University
  • OYAMA Kazunori
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University
  • SONE Mizuki
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University
  • AKAMATSU Atsushi
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University
  • NISHIMORI Katsuhiko
    Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University Laboratory of Molecular Biology, Graduate School of Agricultural Science, Tohoku University

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In mice, homozygous Lgr4 inactivation results in hypoplastic kidneys. To understand better the role of LGR4 in kidney development, we performed an analysis of kidneys in Lgr4-/- embryos. We stained Lgr4-/- kidneys with anti-WT1 and anti-Cleaved Caspase3 antibodies at E16.5, and observed that the structures of the cap mesenchyme were disrupted and that apoptosis increased. In addition, the expression of PAX2, an anti-apoptotic factor in kidney development, was also significantly decreased at E16.5. We found that the LGR4 defect caused an increase in apoptosis in the peripheral mesenchyme during kidney development.

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