Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom<i>Ganoderma lucidum</i>

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  • WENG Yufang
    College of Pharmaceutical Sciences, Zhejiang University
  • LU Jun
    College of Pharmaceutical Sciences, Zhejiang University
  • XIANG Lan
    College of Biosystems Engineering and Food Science, Zhejiang University
  • MATSUURA Akira
    Department of Biology, Faculty of Science, Chiba University
  • ZHANG Yang
    College of Biology and Science, Sichuan Agricultural University
  • HUANG Qianming
    College of Biology and Science, Sichuan Agricultural University
  • QI Jianhua
    College of Pharmaceutical Sciences, Zhejiang University

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  • Ganodermasides C and D, Two New Anti-Aging Ergosterols from Spores of the Medicinal Mushroom Ganoderma lucidum

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Two new anti-aging compounds, ganodermasides C and D, were isolated and their structures elucidated. They are novel ergosterols possessing a 4,6,8(14),22-tetraene-3-one unit with unique hydroxylation at C-9. Both of them significantly extended the replicative lifespan of the K6001 yeast strain. Ganodermasides C and D regulated the expression of the gene for UTH1 to prolong the replicative lifespan of yeast.

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