Efficacy of Oral Administration of a Heat-Killed Lactobacillus gasseri OLL2809 on Patients of Japanese Cedar Pollinosis with High Japanese-Cedar Pollen-Specific IgE

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  • GOTOH Minoru
    Department of Otorhinolaryngology, Nippon Medical School Chiba Hokusoh Hospital
  • SASHIHARA Toshihiro
    Division of Research and Development, Meiji Dairies Corporation
  • IKEGAMI Shuji
    Division of Research and Development, Meiji Dairies Corporation
  • YAMAJI Taketo
    Division of Research and Development, Meiji Dairies Corporation
  • KINO Kohsuke
    Division of Research and Development, Meiji Dairies Corporation
  • ORII Naoki
    Division of Research and Development, Meiji Dairies Corporation
  • TAKETOMO Naoki
    Division of Research and Development, Meiji Dairies Corporation
  • OKUBO Kimihiro
    Department of Otorhinolaryngology, Nippon Medical School Hospital

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  • Efficacy of Oral Administration of a Heat-Killed<i>Lactobacillus gasseri</i>OLL2809 on Patients of Japanese Cedar Pollinosis with High Japanese-Cedar Pollen-Specific IgE

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Abstract

A randomized, double-blind, placebo-controlled clinical trial was conducted to determine whether oral administration of heat-killed Lactobacillus gasseri OLL2809 would affect the immune response and reduce the symptoms of Japanese cedar pollinosis (JCP) in subjects with JCP. Following a 1-week pre-observation period, the subjects were randomly divided into two groups and were orally administered a placebo or tablets containing 100 mg of L. gasseri OLL2809 per d for 8 weeks during the pollen season in 2007. The results showed no obvious differences between the groups. Supplementary subgroup analysis revealed that the OLL2809 subgroups with CAP-RAST scores of 4 or 5 exhibited improvement in nasal symptoms scores and serum allergy-related items, including Japanese cedar pollen-specific IgE levels. L. gasseri OLL2809 was found to be effective in reducing symptoms in subjects with a high predisposition to allergies by modulating systemic immune systems.

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