Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor 7 activating protease) autoactivation
-
- YAMAMOTO Eisaku
- Department of Applied Biological Science, Tokyo University of Agriculture and Technology
-
- KITANO Yoshikazu
- Department of Applied Biological Science, Tokyo University of Agriculture and Technology
-
- HASUMI Keiji
- Department of Applied Biological Science, Tokyo University of Agriculture and Technology
書誌事項
- タイトル別名
-
- Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation
この論文をさがす
抄録
Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. Here we found that compounds with plural catechol groups conjugated with strong electron-withdrawing groups, such as tyrphostin AG 537 (IC50=18 nM), were potent inhibitors of pro-PHBP activation.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 75 (10), 2070-2072, 2011
公益社団法人 日本農芸化学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206477918208
-
- NII論文ID
- 10029873414
-
- NII書誌ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 11286948
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可