Amyloid β induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality
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- NAKAGAWA Kiyotaka
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- KIKO Takehiro
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- KURIWADA Satoko
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- MIYAZAWA Taiki
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- KIMURA Fumiko
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- MIYAZAWA Teruo
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
書誌事項
- タイトル別名
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- Amyloid .BETA. Induces Adhesion of Erythrocytes to Endothelial Cells and Affects Endothelial Viability and Functionality
- Amyloid ベータ induces adhesion of erythrocytes to endothelial cells and affects endothelial viability and functionality
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抄録
It has been suggested that amyloid β-peptide (Aβ) might mediate the adhesion of erythrocytes to the endothelium which could disrupt the properties of endothelial cells. We provide evidence here that Aβ actually induced the binding of erythrocytes to endothelial cells and decreased endothelial viability, perhaps by the generation of oxidative and inflammatory stress. These changes are likely to contribute to the pathogenesis of Alzheimer’s disease.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (10), 2030-2033, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206477940736
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- NII論文ID
- 10029873232
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11286697
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可