Isolation and Structural Determination of the Antifouling Diketopiperazines from Marine-Derived Streptomyces praecox 291-11
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- CHO Ji Young
- Department of Marine Biotechnology, Soon Chun Hyang University
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- KANG Ji Young
- Department of Biotechnology, Pukyong University
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- HONG Yong Ki
- Department of Biotechnology, Pukyong University
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- BAEK Hyo Hyun
- Department of Biology, Soon Chun Hyang University
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- SHIN Hyoun Woong
- Department of Marine Biotechnology, Soon Chun Hyang University
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- KIM Myoung Sug
- Pathology Division, National Fisheries Research and Development Institute
書誌事項
- タイトル別名
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- Isolation and Structural Determination of the Antifouling Diketopiperazines from Marine-Derived <i>Streptomyces praecox</i> 291-11
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Marine derived actinomycetes constituting 185 strains were screened for their antifouling activity against the marine seaweed, Ulva pertusa, and fouling diatom, Navicula annexa. Strain 291-11 isolated from the seaweed, Undaria pinnatifida, rhizosphere showed the highest antifouling activity and was identified as Streptomyces praecox based on a 16S rDNA sequence analysis. Strain 291-11 was therefore named S. praecox 291-11. The antifouling compounds from S. praecox 291-11 were isolated, and their structures were analyzed. The chemical constituents representing the antifouling activity were identified as (6S,3S)-6-benzyl-3-methyl-2,5-diketopiperazine (bmDKP) and (6S,3S)-6-isobutyl-3-methyl-2,5-diketopiperazine (imDKP) by interpreting the nuclear magnetic resonance and high-resolution mass spectroscopy data. Approximately 4.8 mg of bmDKP and 3.1 mg of imDKP were isolated from 1.2 g of the S. praecox 291-11 crude extract. Eight different compositions of culture media were investigated for culture, the TBFeC medium being best for bmDKP and TCGC being the optimum for imDKP production. Two compounds respectively showed a 17.7 and 21 therapeutic ratio (LC50/EC50) to inhibit zoospores, and two compounds respectively showed a 263 and 120.2 therapeutic ratio to inhibit diatoms.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 76 (6), 1116-1121, 2012
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206477976832
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- NII論文ID
- 10030817937
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC38jps1Ghsw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 023768179
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- PubMed
- 22790932
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可