Identification of a Fatty Acyl-CoA Synthetase Gene,<i>lcf2</i><sup>+</sup>, Which Affects Viability after Entry into the Stationary Phase in<i>Schizosaccharomyces pombe</i>

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  • FUJITA Yasuyuki
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University
  • MITA Satoka
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University
  • OHTSUKA Hokuto
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University
  • AIBA Hirofumi
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

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  • Identification of a Fatty Acyl-CoA Synthetase Gene, lcf2+, Which Affects Viability after Entry into the Stationary Phase in Schizosaccharomyces pombe
  • Identification of a fatty acyl-CoA synthetase gene, lcf2+, which affect viability after entry into the stationary phase in Schizosaccharomycespombe

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The lcf1+ gene, which encodes a long chain fatty acyl-CoA synthetase, is necessary for the maintenance of viability after entry into the stationary phase in Schizosaccharomyces pombe. In this study, we analyzed a paralogous gene, SPBP4H10.11c (named lcf2+), and we present evidence that the gene encodes a new fatty acyl-CoA synthetase. The enzyme preferentially recognized myristic acid as a substrate. A Δlcf2 mutant showed increased viability after entry into the stationary phase in SD medium. A Δlcf1Δlcf2 double mutant showed a severe decrease in long-chain fatty acyl-CoA synthetase activity and a rapid loss of viability after entry into the stationary phase. These results suggest that fatty acid utilization and/or metabolism is important to determine viability in the stationary phase.

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