Folic Acid Fortification Ameliorates Hyperhomocysteinemia Caused by a Vitamin B<sub>6</sub>-Deficient Diet Supplemented with <small>L</small>-Methionine

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  • YAMAMOTO Kohei
    The United Graduate School of Agricultural Science, Gifu University The United Graduate School of Agricultural Science, Gifu University
  • ISA Yasuka
    Faculty of Home Economics, Gifu Women's University Faculty of Home Economics, Gifu Women's University
  • NAKAGAWA Tomoyuki
    The United Graduate School of Agricultural Science, Gifu University Faculty of Applied Biological Sciences, Gifu University The United Graduate School of Agricultural Science, Gifu University Faculty of Applied Biological Sciences, Gifu University
  • HAYAKAWA Takashi
    The United Graduate School of Agricultural Science, Gifu University Faculty of Applied Biological Sciences, Gifu University The United Graduate School of Agricultural Science, Gifu University Faculty of Applied Biological Sciences, Gifu University

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  • Folic Acid Fortification Ameliorates Hyperhomocysteinemia Caused by a Vitamin B₆-Deficient Diet Supplemented with L-Methionine
  • Folic Acid Fortification Ameliorates Hyperhomocysteinemia Caused by a Vitamin B<sub>6</sub>-Deficient Diet Supplemented with<scp>L</scp>-Methionine

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Abstract

Vitamin B6 (B6) deficiency affects homocysteine metabolism, and this leads to hyperhomocysteinemia. In this study, we examined i) the effects of B6-deficiency and graduated levels of dietary methionine on homocysteine metabolism, and ii) the effects of fortified folate on homocysteine metabolism. In experiment 1, Wistar male rats were fed a control or a B6-deficient diet supplemented with L-methionine at a level of 3, 6, or 9 g/kg of diet for 5 weeks. The resulting plasma homocysteine levels in the B6-deficient groups increased in relation to the increase in dietary methionine level. Next, in experiment 2, rats were fed a control, B6-deficient, or folate enriched (10 mg pteroylmonoglutamic acid/kg) B6-deficient diet containing L-methionine at 9 g/kg for 5 weeks. Although the B6-deficient diet induced hyperhomocysteinemia, folate fortification ameliorated the plasma homocysteine concentration. Overall, our results indicate that folate fortification ameliorates the hyperhomocysteinemia induced by B6 deficiency and supplemental methionine intake.

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