Sudachitin, a Polymethoxyflavone from <I>Citrus sudachi</I>, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

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  • YUASA Keizo
    Department of Biological Science and Technology, The University of Tokushima Graduate School
  • TADA Kaori
    Department of Biological Science and Technology, The University of Tokushima Graduate School
  • HARITA Genki
    Department of Biological Science and Technology, The University of Tokushima Graduate School
  • FUJIMOTO Tomomi
    Department of Biological Science and Technology, The University of Tokushima Graduate School
  • TSUKAYAMA Masao
    Department of Biological Science and Technology, The University of Tokushima Graduate School
  • TSUJI Akihiko
    Department of Biological Science and Technology, The University of Tokushima Graduate School

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  • Sudachitin, a Polymethoxyflavone from Citrus sudachi, Suppresses Lipopolysaccharide-Induced Inflammatory Responses in Mouse Macrophage-Like RAW264 Cells

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Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.

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