Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom <I>Termitomyces albuminosus</I>

DOI Web Site Web Site PubMed 22 References
  • QU Yuan
    College of Pharmaceutical Sciences, Zhejiang University College of Pharmaceutical Sciences, Zhejiang University
  • SUN Kaiyue
    College of Pharmaceutical Sciences, Zhejiang University College of Pharmaceutical Sciences, Zhejiang University
  • GAO Lijuan
    College of Pharmaceutical Sciences, Zhejiang University College of Pharmaceutical Sciences, Zhejiang University
  • SAKAGAMI Youji
    Graduate School of Bioagricultural Sciences, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya University
  • KAWAGISHI Hirokazu
    Graduate School of Science and Technology, Shizuoka University Graduate School of Science and Technology, Shizuoka University
  • OJIKA Makoto
    Graduate School of Bioagricultural Sciences, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya University
  • QI Jianhua
    College of Pharmaceutical Sciences, Zhejiang University College of Pharmaceutical Sciences, Zhejiang University

Bibliographic Information

Other Title
  • Termitomycesphins G and H, Additional Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus

Search this article

Abstract

Two new cerebrosides, termitomycesphins G and H, were isolated from the edible Chinese mushroom, Termitomyces albuminosus (Berk.) Herm., and exhibited neuritogenic activity against PC12 cells. Their structures and absolute stereochemistry were elucidated by spectroscopic methods and by a comparison of the specific rotation of the hydrogenated products from termitomycesphins H and C. These cerebrosides possessed a unique modification by a hydroxyl group at the middle of the long-chain base, like earlier congeners termitomycesphins A–F. Termitomycesphin G with a 16-carbon-chain fatty acid showed higher neuritogenic activity than that of termitomycesphin H with an 18-carbon-chain fatty acid. This effect was observed within the termitomycesphins, suggesting that the chain length of the fatty acyl moiety played a key role in the neuritogenic activity.

Journal

References(22)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top