Cytotoxic Steroids from the Trunk of Berberis koreana

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  • KIM Ki Hyun
    Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University
  • CHOI Sang Un
    Korea Research Institute of Chemical Technology
  • KIM Chung Sub
    Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University
  • LEE Kang Ro
    Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University

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  • Cytotoxic Steroids from the Trunk of <I>Berberis koreana</I>

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A new steroid, itesmol 3-O-palmitate (1), along with two known steroids were isolated from the trunk of Berberis koreana. The structure of 1 was determined on the basis of spectroscopic analyses involving 2D NMR and chemical reactions. Compound 1 exhibited potential antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (respective IC50 values of 7.41, 9.20, 4.53, and 12.91 μM).

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