Antioxidative Pyranonigrins in Rice Mold Starters and Their Suppressive Effect on the Expression of Blood Adhesion Molecules
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- MIYAKE Yoshiaki
- Faculty of Human Wellness, Tokaigakuen University
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- MOCHIZUKI Mika
- Faculty of Human Wellness, Tokaigakuen University Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
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- ITO Chihiro
- Faculty of Pharmacy, Meijo University
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- ITOIGAWA Masataka
- Faculty of Human Wellness, Tokaigakuen University
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- OSAWA Toshihiko
- Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
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説明
Antioxidants having a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity in rice mold starters, which are used for the preparation of various Japanese fermented foods, and their effectiveness against the expression of blood adhesion molecules were examined. An antioxidant was isolated from the rice mold starters used for shochu and identified as pyranonigrin-S (PG-S) by 1H-NMR, 13C-NMR, and FAB-MS analyses. It was a derivative of pyranonigrin-A (PG-A), which has been isolated as an antioxidant from the rice mold starters. Pyranonigrins PG-A and PG-S were found to exist in spores on rice mold starters which had been prepared by Aspergillus awamori, A. kawachii, and A. saitoi. PG-S exhibited a higher level of DPPH radical scavenging activity than PG-A. PG-A was found to have a significant suppressive effect on the expression of vascular cell adhesion molecule-1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs) induced by tumor necrosis factor-α (TNF-α) (P<0.05).
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 72 (6), 1580-1585, 2008
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206478700288
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- NII論文ID
- 10027528974
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 9566761
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 使用不可