A New, Convenient Cell-Based Screening Method for Small-Molecule Glycolytic Inhibitors

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  • KITAGAWA Mitsuhiro
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • MISAWA Mayuko
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • OGAWA Seiichiro
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • TASHIRO Etsu
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • IMOTO Masaya
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

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Abstract

To counteract active glycolysis in tumors, we developed a new, convenient cell-based screening system to identify an inhibitor of glycolysis. Using this system, we searched for an inhibitor in the synthetic Carbasugar library and found two candidates. It was found that both inhibited glycolysis by suppressing the glucose uptake step in tumor cells.

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