Dietary Coenzyme Q10 Suppressed Hepatic Hydroxymethylglutaryl-CoA Reductase Activity in Laying Hens

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  • HONDA Kazuhisa
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • SANEYASU Takaoki
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • MOTOKI Tohru
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • PARK Yuriko
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University
  • KAMISOYAMA Hiroshi
    Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University

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Abstract

The effects of dietary coenzyme Q10 (CoQ10) on cholesterol metabolism in laying hens were investigated. Dietary CoQ10 significantly reduced egg yolk cholesterol content and suppressed hepatic hydroxymethylglutaryl-CoA reductase (HMGR) activity. It is therefore likely that CoQ10 acts as an HMGR inhibitor in the livers of laying hens, which in turn results in a reduction in egg-yolk cholesterol.

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