Inhibitory Activity of Linoleic Acid Isolated from Proso and Japanese Millet toward Histone Deacetylase
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- ABURAI Nobuhiro
- Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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- ESUMI Yasuaki
- RIKEN(The Institute of Physical and Chemical Research)
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- KOSHINO Hiroyuki
- RIKEN(The Institute of Physical and Chemical Research)
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- NISHIZAWA Naoyuki
- Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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- KIMURA Ken-ichi
- Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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抄録
Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC50=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC50=68 μM) and prostate cancer LNCaP cells (IC50=193 μM). Millet containing linoleic acid might have anti-tumor activity.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 71 (8), 2061-2064, 2007
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206479004288
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- NII論文ID
- 10027518068
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8888105
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可