Gender Difference in ICER I.GAMMA. Transgenic Diabetic Mouse
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- INADA Akari
- Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine SSP Stem Cell Unit, Kyushu University Graduate School of Medicine
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- ARAI Hidenori
- Department of Geriatric Medicine, Kyoto University Graduate School of Medicine
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- NAGAI Kojiro
- Department of Nephrology, Kyoto University Graduate School of Medicine
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- MIYAZAKI Jun-ichi
- Division of Stem Cell Regulation Research G6, Osaka University Graduate School of Medicine
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- YAMADA Yuichiro
- SSP Stem Cell Unit, Kyushu University Graduate School of Medicine
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- SEINO Yutaka
- SSP Stem Cell Unit, Kyushu University Graduate School of Medicine Kansai Electric Power Hospital
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- FUKATSU Atsushi
- Department of Nephrology, Kyoto University Graduate School of Medicine
Bibliographic Information
- Other Title
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- Gender Difference in ICER Iγ transgenic diabetic mouse
- Gender Difference in ICER Ig transgenic diabetic mouse
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Abstract
Few studies have been done to examine gender differences in diabetic mouse models. Here we examined a gender difference in Inducible cAMP Early Repressor (ICER) transgenic (Tg) mice, a diabetic mouse model. Longitudinal changes in diabetes and nephropathy were investigated in male and female Tg mice. Both male and female Tg mice developed severe diabetes early in life due to severely impaired insulin synthesis and decreased β-cell numbers, but only female Tg mice became less hyperglycemic later in life, and most female Tg mice did not develop diabetic nephropathy. Even some female Tg mice that remained hyperglycemic showed less renal expansion than age-matched male Tg mice. Thus the gender difference in the severity of diabetes and diabetic nephropathy was evident with age in this model. This study indicates that sex hormones may play a role in glucose metabolism in diabetic conditions.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 71 (8), 1920-1926, 2007
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390001206479076096
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- NII Article ID
- 10027517569
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 8887430
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed