Three New Taxanes with the 10-Alkoxy Group from the Heartwood of<i>Taxus cuspidata</i>

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  • DONG Mei
    College of Basic Medicinal Sciences, Hebei Medical University
  • ZHANG Man-Li
    Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University
  • WANG Yu-Fang
    Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University
  • ZHANG Xi-Ping
    Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University
  • LI Cun-Fang
    Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University
  • SHI Qing-Wen
    Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University
  • CONG Bin
    College of Basic Medicinal Sciences, Hebei Medical University
  • KIYOTA Hiromasa
    Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University

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  • Three New Taxanes with the 10-Alkoxy Group from the Heartwood of Taxus cuspidata

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Three novel taxanes with the 10-alkoxy group were isolated from heartwood of Taxus cuspidata. The structures were identified as 2α,14β-diacetoxy-10β-ethoxytaxa-11,4(20)-dien-5α-ol (1), 2α,14β-diacetoxy-10β-methoxytaxa-11,4(20)-dien-5α-ol (2), and 2α-acetoxy-10β-ethoxytaxa-11,4(20)-diene-5α,14β-diol (3) on the basis of spectroscopic analysis. These are the first taxanes with an alkoxy moiety on the skeleton.

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