Identification of Pin1-Binding Phosphorylated Proteins in the Mouse Brain
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- TATARA Yota
- Laboratory of Enzymology, Graduate School of Agricultural Science, Tohoku University Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine
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- TERAKAWA Takahiro
- Laboratory of Enzymology, Graduate School of Agricultural Science, Tohoku University Effector Cell Institute, Inc.
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- UCHIDA Takafumi
- Laboratory of Enzymology, Graduate School of Agricultural Science, Tohoku University
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To determine the role of Pin1 in the neurotransmission pathway, Pin1-binding proteins in mouse brain extract were identified. The Pin1-binding proteins were extracted from mouse brain homogenate, and the trypsin-digested peptides were analyzed by nano-liquid chromatography tandem mass spectrometry (LC-MS/MS). Proteins that involve the neurotransmission pathway, such as synapsin I, synapsin II, and calcium/calmodulin-dependent protein kinase type II (CaMKII), were identified in a Mascot search. Pull-down and immunoprecipitation assay indicated that Pin1 binds CaMKII in a phosphorylation-specific manner. It was assumed that Pin1 participates in the neurotransmission pathway involving the phosphorylation signal by CaMKII.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (12), 2480-2483, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206479111296
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- NII論文ID
- 10027728301
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10928596
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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