Proteose Peptone Fraction of Bovine Milk Depressed IgE Production<i>in Vitro</i>and<i>in Vivo</i>
-
- OHNO Fumi
- Faculty of Agriculture, Ehime University
-
- SUGAHARA Takuya
- Faculty of Agriculture, Ehime University South Ehime Fisheries Research Center, Ehime University
-
- KANDA Kota
- Faculty of Agriculture, Ehime University
-
- NISHIMOTO Sogo
- Center for Marine Environmental Studies, Ehime University
書誌事項
- タイトル別名
-
- Proteose Peptone Fraction of Bovine Milk Depressed IgE Production in Vitro and in Vivo
この論文をさがす
抄録
Proteose peptone (PP) is a heat-stable and acid-soluble protein in milk whey. We reveal in this study the IgE production-suppressing activity of the PP fraction in bovine milk. The PP fraction suppressed IgE production by human myeloma cell line U266 cells by depressing the IgE mRNA expression. The suppressive activity of the PP fraction was facilitated by trypsin digestion. An oral administration of the PP fraction significantly decreased the levels of total and ovalbumin (OVA)-specific IgE in the serum collected from OVA-sensitized mice. However, the serum levels of other Ig classes in OVA-sensitized mice were not affected by the intake of the PP fraction. The PP fraction suppressed the mRNA expression level of IgE in mice splenocytes collected from OVA-sensitized mice. Moreover, the B cell population in the spleen was decreased, while the T cell population was increased by administering the PP fraction. These results suggest that the PP fraction modified the B/T cell balance.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 74 (7), 1332-1337, 2010
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206479386496
-
- NII論文ID
- 10027556839
-
- NII書誌ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 10766328
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可