Evaluation of the Protective Effects of Chinese Herbs against Biomolecule Damage Induced by Peroxynitrite
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- LUO Yunjing
- College of Life Science and Bioengineering, Beijing University of Technology
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- PAN Jinglin
- College of Life Science and Bioengineering, Beijing University of Technology
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- PAN Yanshu
- School of Basic Medical Science, Beijing University of Chinese Medicine
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- HAN Zhiguo
- College of Life Science and Bioengineering, Beijing University of Technology
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- ZHONG Rugang
- College of Life Science and Bioengineering, Beijing University of Technology
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抄録
This work evaluates the protective effects of Chinese herbs against ONOO−-induced biomolecule damage. Thirty-two Chinese traditional herbs were preliminarily screened for their ONOO−-scavenging activity by the fluorometric method. The potency of scavenging activity was in the following order: Apis cerana Fabricius (Propolis) > Rosmarinus officinalis L (Rosemary) > Pseudolarix amabilis (Nelson) Rehd. (Pine Bark PE) > Echinacea Moenck. (Echinacea); the remaining twenty-eight herbs performed unsatisfactorily for their scavenging activity. The four extracts with high ONOO− scavenging activity were selected for further characterization of their inhibiting effects on DNA single breaks, tyrosine nitration and LDL oxidation. A further study of the origin of this scavenging activity on the major active components showed cichoric acid and rosemary acid to both have strong ability to scavenge ONOO−. These scavengers might be developed as therapeutic drugs for preventing ONOO−-involved diseases.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (7), 1350-1354, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206479396992
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- NII論文ID
- 10027556922
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10766379
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可