Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from<i>Piper longum</i>on Melanin Production in B16 Mouse Melanoma Cells

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  • OHNO Osamu
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • WATABE Taeko
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • NAKAMURA Kazuhiko
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • KAWAGOSHI Masaru
    FANCL Research Institute, FANCL Corporation
  • UOTSU Nobuo
    FANCL Research Institute, FANCL Corporation
  • CHIBA Tomohiro
    FANCL Research Institute, FANCL Corporation
  • YAMADA Masayoshi
    FANCL Research Institute, FANCL Corporation
  • YAMAGUCHI Kohji
    FANCL Research Institute, FANCL Corporation
  • YAMADA Kaoru
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • MIYAMOTO Kenji
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
  • UEMURA Daisuke
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

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  • Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells

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An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobavachalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

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