Yamabushitake Mushroom (<i>Hericium erinaceus</i>) Improved Lipid Metabolism in Mice Fed a High-Fat Diet
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- HIWATASHI Kazuyuki
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University Akita Research Institute for Food and Brewing (ARIF)
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- KOSAKA Yasuyuki
- Sakamoto Bio Co., Ltd.
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- SUZUKI Nao
- Akita Research Institute for Food and Brewing (ARIF)
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- HATA Keishi
- Akita Research Institute for Food and Brewing (ARIF)
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- MUKAIYAMA Toshiyuki
- Sakamoto Bio Co., Ltd.
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- SAKAMOTO Kenji
- Sakamoto Bio Co., Ltd.
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- SHIRAKAWA Hitoshi
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
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- KOMAI Michio
- Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
書誌事項
- タイトル別名
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- Yamabushitake Mushroom (Hericium erinaceus) Improved Lipid Metabolism in Mice Fed a High-Fat Diet
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The effects of dietary Yamabushitake mushroom (Hericium erinaceus) on lipid metabolism were examined. C57BL/6J mice were fed a high-fat diet containing hot-water extract (HW-E) and an ethanol extract (EtOH-E) of Yamabushitake mushroom. Administration of HW-E or EtOH-E with a high-fat diet for 28 d resulted in a significant decrease in body weight gain, fat weight, and serum and hepatic triacylglycerol levels. Our in vitro experiments indicated that EtOH-E acts as an agonist of peroxisome proliferator-activated receptor α (PPARα). Quantitative analyses of hepatic mRNA levels revealed that EtOH-E administration resulted in up-regulation of mRNA for a number of PPARα-regulating genes in spite of the fact that the gene expression of PPARα did not change. These results suggest that EtOH-E improves lipid metabolism in mice fed a high-fat diet, and that these effects were mediated by modulation of lipid metabolic gene expression, at least in part via activation of PPARα.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (7), 1447-1451, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206479515264
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- NII論文ID
- 10027557410
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3cjgvFahsQ%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10766664
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- PubMed
- 20622452
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可