Hepatoprotective Effects of Purple Potato Extract against D-Galactosamine-Induced Liver Injury in Rats
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- HAN Kyu-Ho
- Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
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- HASHIMOTO Naoto
- Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
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- SHIMADA Ken-ichiro
- Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
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- SEKIKAWA Mitsuo
- Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
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- NODA Takahiro
- Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
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- YAMAUCHI Hiroaki
- Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
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- HASHIMOTO Makoto
- Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
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- CHIJI Hideyuki
- Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women’s College
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- TOPPING David L.
- CSIRO Division of Health Sciences and Nutrition
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- FUKUSHIMA Michihiro
- Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
Bibliographic Information
- Other Title
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- Hepatoprotective Effects of Purple Potato Extract against<scp>D</scp>-Galactosamine-Induced Liver Injury in Rats
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Description
We investigated the hepatoprotective effect of purple potato extract (PPE) against D-galactosamine (GalN)-induced liver injury in rats. PPE (400 mg) was administered once daily for 8 d, and then GalN (250 mg/kg of body weight) was injected at 22 h before the rats were killed. Serum tumor necrosis factor alpha (TNF-α), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and asparate aminotranferase (AST) levels increased significantly after injection of GalN, but PPE inhibited GalN-induced alterations in serum TNF-α, LDH, ALT, and AST levels. Hepatic lipid peroxide and glutathione levels in the control + GalN group were higher and lower respectively than those in the control group, and those in the PPE + GalN group did not differ from that in the control group. The lipid peroxide level in hepatic microsomes treated with 2,2′-azobis (2-amidinopropane) dihydrochloride in the PPE group was significantly lower than that in the control group. This suggests that PPE has hepatoprotective effects against GalN-induced hepatotoxicity via inhibition lipid peroxidation and/or inflammation in rats.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (6), 1432-1437, 2006
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390001206479575040
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- NII Article ID
- 10018530216
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7958972
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed