Hepatoprotective Effects of Purple Potato Extract against D-Galactosamine-Induced Liver Injury in Rats

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  • HAN Kyu-Ho
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
  • HASHIMOTO Naoto
    Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
  • SHIMADA Ken-ichiro
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
  • SEKIKAWA Mitsuo
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
  • NODA Takahiro
    Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
  • YAMAUCHI Hiroaki
    Department of Upland Agriculture, National Agricultural Research Center for the Hokkaido Region
  • HASHIMOTO Makoto
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine
  • CHIJI Hideyuki
    Department of Food Science and Human Nutrition, Faculty of Human Ecology, Fuji Women’s College
  • TOPPING David L.
    CSIRO Division of Health Sciences and Nutrition
  • FUKUSHIMA Michihiro
    Department of Agriculture and Life Science, Obihiro University of Agriculture and Veterinary Medicine

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  • Hepatoprotective Effects of Purple Potato Extract against<scp>D</scp>-Galactosamine-Induced Liver Injury in Rats

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Abstract

We investigated the hepatoprotective effect of purple potato extract (PPE) against D-galactosamine (GalN)-induced liver injury in rats. PPE (400 mg) was administered once daily for 8 d, and then GalN (250 mg/kg of body weight) was injected at 22 h before the rats were killed. Serum tumor necrosis factor alpha (TNF-α), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and asparate aminotranferase (AST) levels increased significantly after injection of GalN, but PPE inhibited GalN-induced alterations in serum TNF-α, LDH, ALT, and AST levels. Hepatic lipid peroxide and glutathione levels in the control + GalN group were higher and lower respectively than those in the control group, and those in the PPE + GalN group did not differ from that in the control group. The lipid peroxide level in hepatic microsomes treated with 2,2′-azobis (2-amidinopropane) dihydrochloride in the PPE group was significantly lower than that in the control group. This suggests that PPE has hepatoprotective effects against GalN-induced hepatotoxicity via inhibition lipid peroxidation and/or inflammation in rats.

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