Low and Medium but Not High Doses of Green Tea Polyphenols Ameliorated Dextran Sodium Sulfate-Induced Hepatotoxicity and Nephrotoxicity
-
- INOUE Hirofumi
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
-
- MAEDA-YAMAMOTO Mari
- National Institute of Vegetable and Tea Sciences, National Agriculture and Food Research Organization
-
- NESUMI Atsushi
- National Institute of Vegetable and Tea Sciences, National Agriculture and Food Research Organization
-
- TANAKA Takuji
- The Tohkai Cytopathology Institute, Cancer Research and Prevention (TCI-CaPP)
-
- MURAKAMI Akira
- Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
この論文をさがす
抄録
Our previous study indicated that a diet containing a high dose (1%) of green tea polyphenols (GTPs) disrupted liver and kidney function via a reduction in antioxidant enzyme and heat shock protein (HSP) levels in both colitis and non-treated ICR mice. In the present study, we assessed the effects of 0.01%, 0.1%, and 1% dietary GTPs on liver and kidney physiological functioning in dextran sulfate sodium (DSS)-exposed and normal mice. GTPs at 0.01% and 0.1% significantly suppressed DSS-increased serum aspartate 2-oxoglutarate aminotransferase (AST) and alanine aminotransferase (ALT) levels. In contrast, GTPs at 1% increased kidney weight, serum creatinine levels, and thiobarbituric acid-reactive substances (TBARs) in both the kidney and the liver in normal mice, as compared with DSS-exposed mice. GTPs at 0.01% and 0.1% remarkably upregulated the expression of heme oxygenase-1 (HO-1) and heat shock protein 70 (HSP70) mRNA in the liver and kidney of mice exposed to DSS, whereas GTPs at 1% abolished it. Our results indicate that low and medium doses of GTPs have beneficial effects on DSS-induced hepatotoxicity and nephrotoxicity via upregulation of self-protective enzymes, while these effects disappeared at a high dose.
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 77 (6), 1223-1228, 2013
公益社団法人 日本農芸化学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001206479804672
-
- NII論文ID
- 10031184685
-
- NII書誌ID
- AA10824164
-
- COI
- 1:STN:280:DC%2BC3sjhtFWitw%3D%3D
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 024646959
-
- PubMed
- 23748761
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可