Influence of HbCO Structure of the Bar-Headed Goose on Photolysis Thermodynamics as Studied by the Nanosecond Laser-Ultrasonic Technique
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- ZHAO Jin-yu
- Laboratory of Modern Acoustics, School of Physics, Nanjing University
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- LI Jia-huang
- Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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- ZHANG Zheng
- Nanjing First Hospital of Nanjing Medical University
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- ZHANG Shu-yi
- Laboratory of Modern Acoustics, School of Physics, Nanjing University
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- QU Min
- Laboratory of Modern Acoustics, School of Physics, Nanjing University
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- HUA Zi-qian
- National Laboratory of Protein Engineering, College of Life Sciences, Peking University
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- SHUI Xiu-ji
- Laboratory of Modern Acoustics, School of Physics, Nanjing University
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- HUA Zi-chun
- Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
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The bar-headed goose, a specialized high-altitude species, has a capacity for high oxygen uptake from a hypoxic environment. It thus has a higher oxygen affinity than other bird species of lower-altitude environments. Oxygen affinity is determined by molecular structures and genetic mutations of hemoglobin (Hb), which can also influence the coordinating structures and dynamics of oxygen-Hb. To explore the structural differences in Hbs as between high and low altitude species, photolysis dynamic parameters, including quantum yield, enthalpy, and conformational volume changes in carboxy-Hbs (HbCO) for the bar-headed goose and low altitude counterparts (the Chinese goose and chicken) were investigated by the laser pumping-probing technique and photoacoustic calorimetry. Comparing the photolysis results for HbCO of the three species, the enthalpy and conformational volume changes of the bar-headed goose were much smaller than those of the others, although the quantum yields of all three species are similar. To explain the possible mechanisms of these differences, modifications of salt bridges and key residue mutations at the α β subunit interfaces of the proteins are described and discussed briefly.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 77 (6), 1251-1257, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206479826176
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- NII論文ID
- 10031184690
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3sjhtFWhsA%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024647028
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- PubMed
- 23748768
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可