Styrene Altered Clock Gene Expression in Serum-Shocked Cultured Human Fibroblasts

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  • MANZELLA Nicola
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche
  • BRACCI Massimo
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche
  • STAFFOLANI Sara
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche
  • STRAFELLA Elisabetta
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche
  • RAPISARDA Venerando
    Department of Internal Medicine and Systemic Diseases, University of Catania
  • VALENTINO Matteo
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche
  • AMATI Monica
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche
  • COPERTARO Alfredo
    ASUR Area 2, Loreto Hospital
  • SANTARELLI Lory
    Department of Clinical and Molecular Sciences, Polytechnic University of Marche

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The circadian clock can regulate the metabolic process of xenobiotics, but little is known as to circadian rhythms can be perturbed by xenobiotics. Styrene is a organic chemical widely used in occupational settings. The effects of styrene on the circadian genes of HuDE cells were evaluated after serum-shocking synchronization. A subtoxic dose of 100 µM of styrene altered the expression of clock genes BMAL1, PER2, PER3, CRY1, CRY2, and REV-ERB-α.

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