Polyphenols in Alcoholic Beverages Activating Constitutive Androstane Receptor CAR
-
- YAO Ruiqing
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- YASUOKA Akihito
- Department of Biological Engineering, Maebashi Institute of Technology
-
- KAMEI Asuka
- Kanagawa Academy of Science and Technology
-
- KITAGAWA Yoshinori
- Institute for Health Care Science, Suntory Wellness Ltd.
-
- ROGI Tomohiro
- Institute for Health Care Science, Suntory Wellness Ltd.
-
- TAIEISHI Norifumi
- Institute for Health Care Science, Suntory Wellness Ltd.
-
- TSURUOKA Nobuo
- Institute for Health Care Science, Suntory Wellness Ltd.
-
- KISO Yoshionobu
- Institute for Health Care Science, Suntory Wellness Ltd.
-
- MISAKA Takumi
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- ABE Keiko
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo Kanagawa Academy of Science and Technology
Search this article
Abstract
The constitutive androstane receptor CAR is a xenosensing nuclear receptor that can be activated by natural polyphenols such as flavonoids and catechins. We examined alcoholic beverage phytochemicals for their ability to activate CAR. HepG2 cells were transfected with CAR expression vector and its reporter gene, and then treated with trans-resveratrol, ellagic acid, β-caryophyllene, myrcene, and xanthohumol. A luciferase assay revealed that ellagic acid and trans-resveratrol activated both human and mouse CAR. Since CAR regulates many genes involved in energy metabolism, the possibility exists that these polyphenols would reduce the risk of certain alcohol-induced metabolic disorders with the help of CAR.
Journal
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 75 (8), 1635-1637, 2011
Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Tweet
Details 詳細情報について
-
- CRID
- 1390001206479885184
-
- NII Article ID
- 10029592077
-
- NII Book ID
- AA10824164
-
- COI
- 1:STN:280:DC%2BC3MjovVSjug%3D%3D
-
- ISSN
- 13476947
- 09168451
-
- NDL BIB ID
- 11222699
-
- PubMed
- 21821919
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed