Lowering effect of an isoflavone-rich fermented soybean extract on the serum cholesterol concentration in female rats with or without ovariectomy but not in male rats
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- KISHIDA Taro
- Department of Biological Resources, Faculty of Agriculture, Ehime University
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- MIZUSHIGE Takafumi
- Department of Biological Resources, Faculty of Agriculture, Ehime University
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- NAGAMOTO Manabu
- Department of Biological Resources, Faculty of Agriculture, Ehime University
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- OHTSU Yohhei
- Department of Biological Resources, Faculty of Agriculture, Ehime University
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- IZUMI Tohru
- Research and Development Division, Kikkoman Corporation
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- OBATA Akio
- Research and Development Division, Kikkoman Corporation
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- EBIHARA Kiyoshi
- Department of Biological Resources, Faculty of Agriculture, Ehime University
書誌事項
- タイトル別名
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- Lowering Effect of an Isoflavone-Rich Fermented Soybean Extract on the Serum Cholesterol Concentrations in Female Rats, with or without Ovariectomy, but Not in Male Rats
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We examined the effect of administering an isoflavone-rich fermented soybean extract (FSBE) on the serum cholesterol concentrations in male rats and in intact and ovariectomized (OVX) female rats. Dietary FSBE decreased the serum cholesterol concentrations in intact female and OVX rats, but did not affect the concentrations in male rats. Dietary FSBE increased the hepatic total and esterified cholesterol contents in the intact female rats, but decreased them in the OVX rats. This hypocholesterolemic effect was not a simple estrogenic effect because it has appeared in some reports that estrogen administration decreased serum cholesterol both male and female rats. Dietary FSBE increased the hepatic low-density lipoprotein receptor (LDLR) gene expression in the intact female rats as has previously been reported from many studies, but did not affect that of the OVX rats. Further investigation is needed into the hypocholesterolemic mechanism of FSBE.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 70 (7), 1547-1556, 2006
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206479916160
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- NII論文ID
- 10018528598
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 7997600
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可