Suppression of Oral Tolerance by<i>Lactococcus lactis</i>in Mice

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  • SAKAI Tohru
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • HIROTA Yuko
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • NAKAMOTO Mariko
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • SHUTO Emi
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • HOSAKA Toshio
    Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
  • MAKINO Seiya
    Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Dairies Corporation
  • IKEGAMI Shuji
    Department of Lactic Acid Bacteria Research, Institute of Food Functionality Research, Division of Research and Development, Meiji Dairies Corporation

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  • Suppression of Oral Tolerance by Lactococcus lactis in Mice

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説明

Although oral ovabumin (OVA) administration suppressed the antibody (Ab) response in OVA-immunized mice, Lactococcus lactis increased OVA-specific IgG2a in these mice. L. lactis increased the casein-specific IgG level in NC/Nga mice fed on a casein diet. The percentage of CD4+CD25+ cells was increased in DO11.10 mice orally given OVA, but this increase of CD4+CD25+ cells were suppressed in L. lactis-fed DO11.10 mice.

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