Award Review : The Molecular Mechanism of Calcification in Aquatic Organisms
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- NAGASAWA Hiromichi
- Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
書誌事項
- タイトル別名
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- The Molecular Mechanism of Calcification in Aquatic Organisms
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Biomineralization is a process of mineral deposition by organisms. Calcium salts are the major component of various biominerals, calcium carbonate being the predominant type in aquatic organisms. The mechanism of biomineralization has been conventionally analyzed by microscopic observation. The findings obtained suggest that minute amounts of organic matrices in biominerals play a key role in biomineralization. We first introduced the methodology of bioactive compound chemistry into this research field. Using various biominerals, such as the exoskeleton and gastroliths of the crayfish, the otoliths and scales of fish, the coccoliths of coccolithophores, bivalve shells, and coral skeleton, a range of organic matrices were purified by simple functional assays, and their chemical structures were determined. The function of each matrix component was estimated by its ability to interact with calcium carbonate and by in vitro crystallization, immunological localization, and site-specific and temporal expression of the encoding genes in the case of proteins and peptides, among other compounds. It was found that there was almost no similarity in chemical structure among organic matrices from various biominerals, but similarity in function was observed, and that made possible the functional classification of organic matrices.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 77 (10), 1991-1996, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206480137984
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- NII論文ID
- 130003381902
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC2c%2FjtFyisA%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024971852
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- PubMed
- 24096676
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可