Preventive Effects of<i>Moringa oleifera</i>(Lam) on Hyperlipidemia and Hepatocyte Ultrastructural Changes in Iron Deficient Rats
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- NDONG Moussa
- Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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- UEHARA Mariko
- Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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- KATSUMATA Shinichi
- Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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- SATO Shigeru
- Central Institute for Electron Microscopic Research, Nippon Medical School
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- SUZUKI Kazuharu
- Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
書誌事項
- タイトル別名
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- Preventive Effects of Moringa oleifera (Lam) on Hyperlipidemia and Hepatocyte Ultrastructural Changes in Iron Deficient Rats
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The effects of Moringa oleifera (MO), Moringaceae on hyperlipidemia and hepatocyte ultrastructural changes caused by iron deficiency were investigated. Four-week-old male Wistar-strain rats were fed a control diet based on AIN-93G (C), an iron deficient diet (FeD), a FeD + 0.5% MO (FeD-m) diet, or a FeD + MO 1% (FeD-M) diet for 4 weeks. It was found that MO reduced iron-deficient diet-induced increases in serum and hepatic lipids with dose-dependent increases of serum quercetin and kaempherol, but did not prevent anemia. By electron microscopy, in iron deficient hepatocytes, slightly swollen mitochondria and few glycogen granules were observed, but glycogen granules increased and mitochondria were normalized by treatment with MO. Furthermore, lipoproteins were observed in the Golgi complex under treatment with MO. These results suggest a possible beneficial effect of MO in the prevention of hyperlipidemia and ultrastructural changes in hepatocytes due to iron-deficiency.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 71 (8), 1826-1833, 2007
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206480290816
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- NII論文ID
- 10027517173
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8887135
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可