Linoleic Acid Promotes Mitochondrial Biogenesis and Maintains Mitochondrial Structure for Prevention of Streptozotocin Damage in RIN-m5F Cells

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  • JENG Jaan-Yeh
    Department of General Surgery, Cathay General Hospital Graduate Institute of Medical Science, Taipei Medical University
  • YEH Tien-Shun
    Institute of Anatomy and Cell Biology, Yang-Ming University
  • CHIU Yi-Hua
    Graduate Institute of Medical Science, Taipei Medical University School of Nutrition and Health Sciences, Taipei Medical University
  • LEE Yu-Chieh
    Graduate Institute of Medical Science, Taipei Medical University
  • CHENG Hsing-Hsien
    School of Nutrition and Health Sciences, Taipei Medical University
  • HSIEH Rong-Hong
    School of Nutrition and Health Sciences, Taipei Medical University

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Linoleic acid (LA) improves insulin resistance and prevents diabetes. To investigate whether linoleic acid could protect against streptozotocin (STZ)-induced cell death, rat RIN-m5F cells were exposed to STZ. SL and SO groups consisted of cells treated with STZ and then LA or oleic acid (OA) respectively. STZ treatment decreased the mitochondrial membrane potential in the STZ, SO, and SL groups. Cells of the SL group had more intact mitochondria. Increased mRNA expression of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), as well as of the mitochondrial biogenesis regulators peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α), and mitochondrial transcription factor A (Tfam), were found in the LA group. The insulin content was significantly decreased in all three groups. These results suggest that the effects of LA on cell viability after STZ damage occur through maintenance of mitochondrial structure and increased mitochondrial biogenesis.

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