Induction of Apoptosis in DLD-1 Human Colon Cancer Cells by Peridinin Isolated from the Dinoflagellate, Heterocapsa triquetra

DOI Web Site Web Site 2 Citations 15 References
  • SUGAWARA Tatsuya
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
  • YAMASHITA Kyoko
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
  • SAKAI Shota
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
  • ASAI Akira
    National Food Research Institute
  • NAGAO Akihiko
    National Food Research Institute
  • SHIRAISHI Tomotaka
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
  • IMAI Ichiro
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
  • HIRATA Takashi
    Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University

Bibliographic Information

Other Title
  • Induction of Apoptosis in DLD-1 Human Colon Cancer Cells by Peridinin Isolated from the Dinoflagellate,<i>Heterocapsa triquetra</i>

Search this article

Abstract

Peridinin, which is uniquely present in dinoflagellates, is one of the most abundant carotenoids found in nature. We evaluated the apoptotic effect of peridinin on DLD-1 human colorectal cancer cells. Peridinin significantly reduced the cell viability in a dose-dependent manner (0–20 μM) and induced apoptosis by activating both caspase-8 and caspase-9. Our findings could be important for the high-performance utilization of marine bioproducts.

Journal

Citations (2)*help

See more

References(15)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top