Prevention of pathogenic escherichia coli infection in mice and stimulation of macrophage activation in rats by an oral administration of probiotic lactpbacillus casei I-5
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- ISHIDA-FUJII Keiko
- R & D Center, Japan Alcohol Corporation
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- SATO Rieko
- R & D Center, Japan Alcohol Corporation
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- GOTO Shingo
- R & D Center, Japan Alcohol Corporation
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- YANG Xiao-Ping
- Environmental Research Center, Mercian Cleantec Corporation
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- KUBOKI Hiroshi
- Environmental Research Center, Mercian Cleantec Corporation
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- HIRANO Shin-ichi
- Environmental Research Center, Mercian Cleantec Corporation
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- SATO Michikatsu
- R & D Center, Japan Alcohol Corporation
書誌事項
- タイトル別名
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- Prevention of Pathogenic Escherichia coli Infection in Mice and Stimulation of Macrophage Activation in Rats by an Oral Administration of Probiotic Lactobacillus casei I-5
- Prevention of Pathogenic<i>Escherichia coli</i>Infection in Mice and Stimulation of Macrophage Activation in Rats by an Oral Administration of Probiotic<i>Lactobacillus casei</i>I-5
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Lactobacillus casei I-5 isolated from an alcohol fermentation broth enhanced immunity and prevented pathogenic infection as a probiotic. Mice fed with I-5 cells for 11 days prior to an intraperitoneal challenge with pathogenic Escherichia coli Juhl exhibited a high survival rate compared with the control group. Rats fed with I-5 cells for 10 days significantly increased the phagocytosis of peritoneal macrophages. In a cell culture system employing peritoneal macrophages from rats, the I-5 administration activated NF-κB stimulated by LPS. It also enhanced LPS-stimulated IL-12 and TNF-α production, but not IL-6 production. These results show that L. casei I-5 effectively prevented infection by pathogenic E. coli possibly through the activation of peritoneal macrophages. The strain would be useful to prevent pathogenic microbial infections in humans and farm animals.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 71 (4), 866-873, 2007
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206480591104
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- NII論文ID
- 10027513241
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8714919
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可