Syntheses and Conformations of Poly (<SUB>L</SUB>-methionine-<I>co</I>-<SUB>L</SUB>-homocysteine) s

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  • NAKAJIMA Bun-ichiro
    Department of Polymer Science, Faculty of Science, Hokkaido University
  • NISHI Norio
    Department of Polymer Science, Faculty of Science, Hokkaido University
  • NOGUCHI Junzo
    Department of Polymer Science, Faculty of Science, Hokkaido University

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Other Title
  • コポリ（Ｌ‐メチオニン，Ｌ‐ホモシステイン）の合成とその分子形態
  • コポリ L メチオニン L ホモシステイン ノ ゴウセイ ト ソノ ブンシ ケ

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Abstract

Poly (L-methionine) was converted by reduction with sodium in liquid ammonia under various conditions into seven kinds of poly (L-methionine-co-L-homocysteine) s having the homocysteine contents of 11, 19, 26, 44, 72, 81, and 88% (mol%). The conversion into L-homocysteine units of up to 80% can be reproduced under relatively mild conditions. Although the solubilities of the copolymers in organic solvents decrease with an increase of homocysteine content, all the copolymers prepared are soluble in methanesulfonic acid and trifluoromethanesulfonic acid. The copolymers were found to have a random coil conformation in methanesulfonic acid and a random coil structure containing some ahelical conformation in dichloroacetic acid, by viscometric measurement and optical rotatory dispersion. On the other hand, their conformations in a solid state were determined to be a mixture of α-helix and β-form from the infrared absorption spectra.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 36 (9), 629-634, 1979

    The Society of Polymer Science, Japan

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