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- 樋口 真弘
- 産業技術総合研究所界面ナノアーキテクトニクス研究センター
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- WRIGHT Jonathan P.
- Nanoarchitectonics Research Center, National Institute of Advanced Industrial Science and Technology
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- 田口 和宏
- 産業技術総合研究所界面ナノアーキテクトニクス研究センター
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- 木下 隆利
- 名古屋工業大学材料工学科
書誌事項
- タイトル別名
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- Polymer Micelles II. Structure and Molecular Recognition Properties of an Amphiphilic Poly(allylamine) Micelle Containing Poly(L-alanine) Graft Chains.
- グラフトガタ リョウシンバイセイ ポリペプチド ニ ヨル ミセル ケイセイ ト アミノサン ニンシキ
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説明
An amphiphilic polymer, poly (allylamine) (MW=10000) containing 30 mol% hydrophobic poly (L-alanine) graft chains (MW=1065) (PAAgPAla) was prepared. PAAgPAla formed micelles in aqueous solutions. The size of the PAAgPAla micelle increased with increasing pH, reflecting ionization changes in the allylamine moiety in the main chain. In alkaline conditions, the PAAgPAla poly (L-alanine) graft chains were found to self-assemble owing to the absence of the electrostatic repulsions among the neighboring allylamine moieties, to yield β-sheet structure domains in the micelle. We investigated the molecular recognition properties of the PAAgPAla micelle at pH 10.0 using surface plasmon resonance measurements. Active domains composed from the poly (L-alanine) self-assembly in the micelle interact specifically with aqueous L-phenylalanine rather than with its D-isomer. The binding of L-phenylalanine to the PAAgPAla micelle exhibited Langmuir-type saturation behavior, with its affinity constant (K=3.4X105 M-1) being 7.2 times larger than that observed for its affinity for D-phenylalanine (K=4.7X104 M-1) The poly (L-alanine) domain in the PAAgPAla micelle was confirmed as a binding site for L-phenylalanine molecules.
収録刊行物
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- 高分子論文集
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高分子論文集 58 (6), 267-272, 2001
公益社団法人 高分子学会
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詳細情報 詳細情報について
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- CRID
- 1390001206521960704
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- NII論文ID
- 10006094589
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- NII書誌ID
- AN00085011
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- ISSN
- 18815685
- 03862186
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- NDL書誌ID
- 5818726
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可
