結晶セルロースの粒子形態が錠剤圧縮性に及ぼす影響 第２報 結晶セルロース粒子の配向性が圧縮成形特性に及ぼす影響
書誌事項
- タイトル別名
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- Effect of Orientation of Microcrystalline Cellulose Particles on Tablet Compression Properties.
説明
The purpose of this study is to establish the mechanism of generation of high tensile strength (T) in a tablet consisting of microcrystalline cellulose (MCC) particles with large L/D (L, length; D, width). An attempt was made to clarify particle orientation in a tablet by examining inner structure of the tablet using scanning electron microscopy and X-ray diffraction measurement. By observing the surface of MCC particles treated with cellulase, cellulose microfibrils were found to be oriented along longitude of the particle, and it seemed that the degree of crystallite orientation δ was correspondent with the degree of MCC particle orientation. Comparing δ among tablets consisting of MCC particles with different L/D, we found that δ increased with an increase in L/D and that the larger the L/D, the more highly MCC particles were oriented along the direction at right angles to the direction of compression, because MCC particles with a larger L/D might undergo a larger moment for rotating themselves so as to orient the MCC particles along the direction. We came to the conclusions that MCC particles with larger L/D could be easily oriented during compression, resulting in generation of a larger contacting inner surface among the MCC particles, so that the tablet consisting of the MCC particles with larger L/D exhibited larger T.
収録刊行物
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- 高分子論文集
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高分子論文集 56 (3), 141-150, 1999
公益社団法人 高分子学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390001206522357376
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- NII論文ID
- 130004035364
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- ISSN
- 18815685
- 03862186
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
