Cellular response to fibrin formed on polymer surface.

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  • TOMINAGA Naoki
    Department of Material Systems Engineering, faculty of Technology, Tokyo University of Agriculture and Technology
  • SUGAO Masaichi
    Department of Material Systems Engineering, faculty of Technology, Tokyo University of Agriculture and Technology
  • AKAIKE Toshihiro
    Department of Material Systems Engineering, faculty of Technology, Tokyo University of Agriculture and Technology

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Other Title
  • 高分子材料表面に形成されたフィブリンに対する細胞接着
  • コウブンシ ザイリョウ ヒョウメン ニ ケイセイサレタ フィブリン ニ タイス

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Abstract

In order to clarify how structures of fibrin are related to cellular attachment and how polymer materials affect cellular responses and fibrin structures, the responses of fibroblast (adhesion, growth and morphological changes) to fibrin fiber gel coated on sulfonated-polystyrene with varied negative charges were examined. It was found that negative charges on sulfonated-polystyrene surface affected fibrinogen-fibrin conversion, changed structures of fibrin gel formed on sulfonated-polystyrene and furthermore changed cellular responses. The results offer us fundamental informations about biomaterial design of artificial skin and artificial vessel.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 42 (11), 739-745, 1985

    The Society of Polymer Science, Japan

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