混合ロール法によるポリビニルピロリドン‐フェナセチン系の固体混合と薬物の溶解性挙動

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タイトル別名
  • Solid State Mixing of Polyvinylpyrrolidone-Phenaeetin System by Mixing Roll Procedure and Dissolution Behaviors
  • コンゴウ ロールホウ ニ ヨル ポリビニルピロリドン フェナセチンケイ ノ コ

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説明

To increase a dissolution rate of very slightly soluble drugs, the behaviors of dissolution process were extensively investigated in the solid mixing system of polyvinylpyrrolidone (PVP) and phenacetin prepared by procedures of mixing roll (I), coprecipitation (II) and physical mixing (III). The dissolution rate of the drug in the system of powder state below 100 mesh prepared by the procedure I increased as the PVP content increased up to the weight ratio 5 of PVP to the drug. The procedure I was more effective in improving dissolution behavior than the procedure II and III. Microcrystalline phenacetin, slightly present in the system pretreated by the procedure I at the weight ratio 2, was converted to an amorphous state by annealing at 90°C for 1 h. The annealed system exhibited prominent dissolution process of drug.

収録刊行物

  • 高分子論文集

    高分子論文集 41 (5), 307-310, 1984

    公益社団法人 高分子学会

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