Preparation of capsules containing drug with porous particles. V. A sustained release system using porous cellulose spheres modified by grafting as matrices.

HOSOI Fumio, SAITO Kenji, MAKUUCHI Keizou, KOISHI Masumi

doi:10.1295/koron.44.885

Bibliographic Information

Other Title

多孔性微粒子を用いた薬物含有カプセルの調製　Ｖ　　多孔性セルロース微粒子をマトリックスとした薬物徐放性製剤の調製

Description

Polymer-coated spheres, obtained by the graft polymerization of methyl methacrylate (MMA) onto porous spheres based on cellulose by the pre-irradiation method, were used as matrices for the drug sustained release system for salicylic acid. The adsorption of salicylic acid was carried out by dipping the grafted spheres in a 50% aqueous ethanol solution containing salicylic acid. The amount of salicylic acid adsorbed (Q) increased proportionately with the percent graft of MMA (G) to the power of 2.9. Adsorption mechanism of salicylic acid could be expressed in term of Langmuir's adsorption isotherm. The ratio of constants for adsorption and desorption (k) and the saturated amount of salicylic acid adsorbed (Q₀) were expressed as k=k₁G and Q₀=k₂G^2.4, respectively. These results indicate that the number of adsorption sites increased proportionately with the nth power of G as a results of the interaction of grafted poly (methyl methacrylate) (PMMA) and cellulose. Similar results were obtained with grafting of MMA, MMA-styrene (St), and MMA-methacrylic acid (MAc) in the presence of salicylic acid.

Journal

KOBUNSHI RONBUNSHU

KOBUNSHI RONBUNSHU 44 (12), 885-891, 1987

The Society of Polymer Science, Japan

Keywords

Details 詳細情報について

CRID: 1390001206523548800

NII Article ID: 130003837044

DOI: 10.1295/koron.44.885

ISSN: 18815685; 03862186

Text Lang: ja

Data Source

JaLC
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CiNii Articles

Abstract License Flag: Disallowed

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