人工赤血球ポリ（Ｎ?Qα?R，Ｎ?Qε?R‐テレフタロイル‐Ｌ‐リジン）膜と血清タンパク質の相互作用

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タイトル別名
  • Interactions of Poly (<I>N</I><SUP>α</SUP>, <I>N</I><SUP>ε</SUP>-terephthaloyl-L-lysine) Membrane for Artificial Red Blood Cells with Serum Proteins
  • ジンコウ セッケッキュウヨウ ポリ Nアルファ Nイプシロン テレフタロイルー

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The interactions between poly (Nα, Nε-terephthaloyl-L-lysine) membrane (PPL membrane), an artificial red cell membrane, and serum proteins were studied at different pH and ionic strengths of the medium. PPL membrane was prepared by an interfacial polycondensation reaction between L-lysine dissolved in the aqueous phase and terephthaloyl dichloride dissolved in the organic phase. The interactions were found to depend strongly on the pH of the medium while the ionic strength had little or no effect. At pH 2.0, the proteins with a high positive net charge were adsorbed on the negatively charged surface of PPL membrane to lower the zeta potential of the microcapsules, thereby causing their aggregation to a great extent. Since the proteins bore only a very low positive net charge at pH 4.0, their electrostatic interactions with the capsules were weak ; the protein adsorption decreased to decline zeta potential lowering and capsule aggregation. Neither protein adsorption nor capsule aggregation was observed at pH 7.0 where both the capsules and the proteins were negatively charged.

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  • 高分子論文集

    高分子論文集 36 (4), 197-201, 1979

    公益社団法人 高分子学会

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