生体セラミックスの表面機能化技術の開発

DOI Web Site BIBCODE 参考文献63件
  • 紋川 亮
    東京都立産業技術研究センター　バイオ応用技術グループ

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タイトル別名
  • Surface modification of bioceramics
  • 日本鉱物科学会応用鉱物科学賞第4回受賞者 受賞記念研究紹介 生体セラミックスの表面機能化技術の開発
  • ニホン コウブツ カガクカイ オウヨウ コウブツ カガクショウ ダイ4カイ ジュショウシャ ジュショウ キネン ケンキュウ ショウカイ セイタイ セラミックス ノ ヒョウメン キノウカ ギジュツ ノ カイハツ

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  Hydroxyapatite [Ca10(PO4)6(OH)2, HAp] is a major inorganic component of bone and teeth tissues and has the excellent biocompatibility and high osteoconductivity. The interactions between HAp and protein or cell have been studied. The HAp related bioceramics such as bone substitute, coating substance of metal implants, inorganic-polymer composites, and cell culture. We described two methods; (1) surface modification of HAp using organosilane; (2) fabrication of HAp ultra-thin layer on gold surface for protein adsorption analyzed with QCM-D technique. The interfacial interaction between collagen and HAp in a nano-region was controlled by depositing the organosilane of n-octadecyltrimethoxysilane (ODS: -CH3) or aminopropyltriethoxysilane (APTS: -NH2) with a chemical vapor deposition method. The morphologies of collagen adsorbed on the surfaces of HAp and HAp deposited with APTS were similar, however that of the surface with ODS was apparently different, due to the hydrophobic interaction between the organic head group of -CH3 and residual groups of collagen. We present a method for coating gold quartz crystal microbalance with dissipation (QCM-D) sensor with ultra-thin layer of hydroxyapatite nanocrystals evenly covering and tightly bound to the surface. The hydroxyapatite sensor operated in liquid with high stability and sensitivity. The in-situ adsorption mechanism and conformational change of fibrinogen on gold, titanium and hydroxyapatite surfaces were investigated by QCM-D technique and Fourier-transform infrared spectroscopy. The study indicates that the hydroxyapatite sensor is applicable for qualitative and conformational analysis of protein adsorption.<br>

収録刊行物

  • 岩石鉱物科学

    岩石鉱物科学 41 (1), 26-32, 2012

    一般社団法人　日本鉱物科学会

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