Improvement of Fibroblast Adhesion on Poly(.EPSILON.-caprolactone) and Chalcone Blend Films by Roll Drawing and Evaluation of Their Cytotoxicity

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  • NARITA Takefumi
    Genome Biotechnology Laboratory, Kanazawa Institute of Technology
  • OSAWA Satoshi
    Genome Biotechnology Laboratory, Kanazawa Institute of Technology

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Other Title
  • ポリカプロラクトン／カルコン混練フィルムのロール延伸が線維芽細胞の接着および細胞毒性に与える影響
  • ポリカプロラクトン カルコンコンレンフィルム ノ ロール エンシン ガ センイ ガ サイボウ ノ セッチャク オヨビ サイボウ ドクセイ ニ アタエル エイキョウ
  • Improvement of Fibroblast Adhesion on Poly(ε-caprolactone) and Chalcone Blend Films by Roll Drawing and Evaluation of Their Cytotoxicity

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Description

In this study we investigated the effect of roll drawing of poly(ε-caprolactone) (PCL)/chalcone blend film on fibroblast adhesion and toxicity of chalcone for the adhered fibroblast. The number of fibroblast on the roll drawn blend film increased with draw. The inhibitory concentration (IC50) for roll drawn PCL/chalcone blend film was about 2.5 times higher than that for undrawn films. Higher-order structures of the blend films were analyzed by wide-angle X-Ray diffraction and differential scanning calorimetry. The crystallinity and molecular orientation of the blend film increased with increasing the draw ratio, especially, the (200) plane oriented parallel to the film surface. The structural change by the roll draw was closely related with the cell adhesion and the IC50.<br>

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 67 (2), 117-122, 2010

    The Society of Polymer Science, Japan

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