Molecular Characterization of Poly(<small>L</small>-Lactic Acid) Isolated Chain

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  • SAITO Yuta
    Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University
  • IZUTA Daiki
    Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University
  • KANEKO Norifumi
    Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University
  • TOGASHI Daichi
    Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University
  • NARUMI Atsushi
    Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University
  • KAWAGUCHI Seigou
    Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University

Bibliographic Information

Other Title
  • ポリ(<small>L</small>-乳酸) (PLLA)孤立鎖の分子特性解析
  • ポリ(L-乳酸)(PLLA)孤立鎖の分子特性解析
  • ポリ(L-ニュウサン)(PLLA)コリツ サ ノ ブンシ トクセイ カイセキ
  • Molecular Characterization of Poly(L-Lactic Acid) Isolated Chain

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Abstract

Poly(L-lactic acid) (PLLA) was studied by size exclusion chromatography equipped with a multi-angle light scattering on-line detector (SEC-MALS) in CHCl3 or 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as eluent. A large discrepancy in the weight-averaged molecular weight, Mw determined by the light scattering in HFIP and determined by the conventional SEC was observed, which is most likely due to the chemical structural difference between PLLA and standard samples used for the SEC measurement. Reliable Mw values were obtained only by SEC-MALS measurements in HFIP. The Mw-dependence of ⟨S2⟩z1/2 of PLLA can be described by the equation ⟨S2⟩z1/2 (nm) = 2.3 × 10−2Mw0.60 in HFIP at 25°C. Also, the Mw-dependence of [η] of PLLA chains at 25°C can be expressed by the equations [η] (mL/g) = 3.3 × 10−2Mw0.74 in CHCl3 and [η] (mL/g) = 4.4 × 10−2Mw0.71 in HFIP. The characteristic ratio (C∞) was determined to be 11.2 ± 0.7 from the ⟨S2⟩z1/2 and [η] measurements. We conclude that PLLA behaves as typical flexible chain polymer perturbed by the excluded volume effects in CHCl3 and HFIP.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 69 (7), 416-423, 2012

    The Society of Polymer Science, Japan

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