Characterization of Polymer Micelles by the Combination of SAXS and FFF-MALS

DOI Web Site 3 Citations 44 References
  • SANADA Yusuke
    Department of Chemistry and Biochemistry, The University of Kitakyushu
  • AKIBA Isamu
    Department of Chemistry and Biochemistry, The University of Kitakyushu
  • HASHIDA Satoshi
    Department of Chemistry and Biochemistry, The University of Kitakyushu
  • SHIRAISHI Kouichi
    Medical Engineering Laboratory, Research Center for Medical Science, Jikei University School of Medicine
  • YOKOYAMA Masayuki
    Medical Engineering Laboratory, Research Center for Medical Science, Jikei University School of Medicine
  • YAGI Naoto
    Japan Synchrotron Radiation Research Institute (JASRI/SPring-8)
  • SHINOHARA Yuya
    Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo
  • AMEMIYA Yoshiyuki
    Department of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo
  • SAKURAI Kazuo
    Department of Chemistry and Biochemistry, The University of Kitakyushu

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Other Title
  • SAXSとFFF-MALSを組合せた高分子ミセルのキャラクタリゼーション
  • SAXS ト FFF-MALS オ クミ アワセタ コウブンシ ミセル ノ キャラクタリゼーション

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Description

Poly(ethylene glycol)-block-poly(partially benzyl-esterified aspartic acid), denoted by PEG-P(Asp(Bzl)), is one of the most examined blockcopolymers for drug carriers. However, little is known about its fundamental physical properties. Nine samples of PEG-P(Asp(Bzl)) with different benzylation fraction (FBzl) and aspartic chain length (DPAsp) were synthesized and the aggregation number (Nagg), the core radius (RC) and other structural parameters were determined with a combination of light scattering and synchrotron X-ray small-angle scattering. The major factor to determine Nagg and RC was found to be FBzl, i.e., the hydrophobic nature of the core, even though FBzl was changed in a relatively small composition range from 66–89 mol%. The overcrowding nature of the tethered PEG chains on the micelles increased about 1.5–3 times with increasing Nagg compared with the unperturbed state in solutions.

Journal

  • KOBUNSHI RONBUNSHU

    KOBUNSHI RONBUNSHU 69 (7), 346-357, 2012

    The Society of Polymer Science, Japan

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